How Long Does Tylenol 3 stay in Your System

What is Tylenol with Codeine #3

Tylenol with Codeine #3 is a medication that is used to treat mild to moderate pain. Its two main ingredients are acetaminophen and codeine. The medication may also be used to treat a cough.

How long does Tylenol 3 stay in your system

We must consider the elimination half-lives of Tylenol 3’s two principal components, codeine, and acetaminophen.

Acetaminophen half-life

Acetaminophen has an elimination half-life of 1-4 hours. This means that it takes 5.5-22 hours for the acetaminophen component of Tylenol 3 to be eliminated from the system.

Codeine half-life

Terminal half-life for codeine is 2.9 hours, or 2 hours 54 minutes. It would take close to 16 hours for this drug to be eliminated from your body.

Taking the above into consideration, it can be safely concluded that Tylenol 3 will be excreted from your system 24 hours after the final dose.

This, however, is an estimate based on the average human being. In actuality, factors like age, liver condition, urinary pH level, metabolic rate, duration and frequency of the dosage, and whether any other drugs are co-consumed that may help or hinder the speed at which the liver metabolizes Tylenol 3.

How long is Tylenol 3 detectable urine, blood, saliva and hair follicle drug test
Urine test	8-24 hours
Blood test	12 hours
Saliva test	1-2 days
Hair follicle test	Up to 90 days, but often unreliable