Robitussin DM is an over-the-counter cough medicine with the active ingredients guaifenesin and dextromethorphan. The former is an expectorant while the latter is a mild narcotic with antitussive properties.
The half-life of Robitussin in people with normal metabolic rates has been observed to be around 2-4 hours; somebody with a poor metabolic rate could take up to 3-6 hours to excrete half of the Robitussin they have taken.
Thus we can conclude that individuals with a normal metabolic rate are expected to eliminate the dextromethorphan within Robitussin 11-22 hours after they take it for the last time, while a person with a poor metabolic rate is going to take 16½-33 hours to excrete the same amount of ingested dextromethorphan.
Guaifenesin, on the other hand, has an elimination half-life of 1-5 hours, meaning it would take around 5½-27½ hours for the body to completely get rid of guaifenesin.
In any case, Robitussin will be completely eliminated from your body after a maximum duration of 33 hours after your last dose.
Robitussin AC is another form of Robitussin with codeine as the active ingredient, it is available only with a prescription.
To know more about how long codeine stays in the system, click here.
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